Transdermal patches are the least invasive of available drug delivery techniques. Since their approval for clinical use in transdermal patches have become ideal carriers for a variety of drugs. Although transdermal patches are very promising, even wider application of this drug-delivery technique is still hindered by two main factors: the limited permeability of the human skin and the absence of a cheap, reliable and versatile patch that can release well-controlled dosages of a variety of drugs at precise time intervals over a long period.
This project aims to design a smart controllable membrane, which combines the simplicity of a membrane based patch with the precise drug delivery of a complex micro-machine based system. This has the potential to decrease the cost and increase the applicability of transdermal delivery. The aim of the research is to investigate whether a modeling approach encompassing two complementary simulation techniques in an integrated framework can be used to design a smart membrane. Specifically, the goal of the proposed research is to investigate how porous membrane surface features could be rationally designed for precise flow control.